Drug General Information
Drug ID	D0N8BJ
Former ID	DIB018222
Drug Name	[3H]5-HT
Synonyms	[3H]-5-HT
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540221]
Structure		Download 2D MOL
Formula	C10H12N2O
InChI	InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/i3T,4T
InChIKey	QZAYGJVTTNCVMB-PZFLKRBQSA-N
PubChem Compound ID	53317992
PubChem Substance ID	124958847, 135651129
Target and Pathway
Target(s)	5-hydroxytryptamine 1D receptor	Target Info	Agonist	[534635]
	5-hydroxytryptamine 1E receptor	Target Info	Agonist	[527679]
	5-hydroxytryptamine 7 receptor	Target Info	Agonist	[533934]
	5-hydroxytryptamine 2B receptor	Target Info	Agonist	[534042]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapsehsa04024:cAMP signaling pathway
	Serotonergic synapsehsa04014:Ras signaling pathway
	Calcium signaling pathway
	Serotonergic synapsehsa04020:Calcium signaling pathway
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04374:5HT2 type receptor mediated signaling pathway
PathWhiz Pathway	Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
Reactome	Serotonin receptors
	G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (q) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
	GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
	GPCR downstream signaling
	GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Gastrin-CREB signalling pathway via PKC and MAPK
References
Ref 540221	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3248).
Ref 527679	Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype. Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5517-21.
Ref 533934	Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. J Biol Chem. 1993 Nov 5;268(31):23422-6.
Ref 534042	Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor. Mol Pharmacol. 1993 Mar;43(3):419-26.
Ref 534635	Br J Pharmacol. 1998 Apr;123(8):1655-65.Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.