Drug Information

Drug General Information
Drug ID
D0N8EL
Former ID
DIB020898
Drug Name
SB 204070
Synonyms
SB-204070A; SB204070; SB-204,070
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539653]
Structure
Download
2D MOL
Formula
C19H27ClN2O4
InChI
InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3
InChIKey
AOOSJYIINXVNHV-UHFFFAOYSA-N
PubChem Compound ID
121881
PubChem Substance ID
7980564, 10239848, 11111796, 12014808, 14780258, 24263017, 29302378, 47275548, 47646558, 48243364, 50070828, 50111228, 57339824, 75579289, 85209377, 103260538, 104414499, 124750197, 124881433, 126434928, 127436804, 135154729, 135650983, 136350476, 142607968, 162223684, 179235764, 196374288, 227291190
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Antagonist [534429]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 539653(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 256).
Ref 534429[3H]RS 57639, a high affinity, selective 5-HT4 receptor partial agonist, specifically labels guinea-pig striatal and rat cloned (5-HT4S and 5-HT4L) receptors. Neuropharmacology. 1997 Apr-May;36(4-5):671-9.

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