Drug Information

Drug General Information
Drug ID
D0N8FQ
Former ID
DAP000720
Drug Name
Reboxetine
Synonyms
Davedax; Edronax; Esreboxetine; Norebox; Prolift; Reboxitine; Solvex; Vestra; Reboxetine [INN]; Reboxetine mesylate; Davedax (TN); Edronax (TN); Norebox (TN); Prolift (TN); Reboxetine (INN); Solvex (TN); Vestra (TN); Esreboxetine (USAN/INN); (+-)-(2R*)-2-((alphaR*)-alpha-(o-Ethoxyphenoxy)benzyl)morpholine; (2R)-2-[(R)-(2-ethoxyphenoxy)-phenylmethyl]morpholine; (2R)-2-[(S)-(2-ethoxyphenoxy)-phenylmethyl]morpholine; (2S)-2-[(S)-(2-ethoxyphenoxy)-phenylmethyl]morpholine; (S,S)-Reboxetine; (S,S)-reboxetine; 2-((2-ethoxyphenoxy)benzyl)morpholine methanesulfonate; 2-[(2-ethoxyphenoxy)-phenylmethyl]morpholine
Drug Type
Small molecular drug
Indication Depression [ICD9: 311; ICD10:F30-F39] Approved [468039], [536306]
Therapeutic Class
Antidepressants
Company
Pfizer Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C19H23NO3
InChI
InChI=1S/C19H23NO3/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18/h3-11,18-20H,2,12-14H2,1H3/t18-,19-/m0/s1
InChIKey
CBQGYUDMJHNJBX-OALUTQOASA-N
CAS Number
CAS 98769-81-4
PubChem Compound ID
65856
PubChem Substance ID
8189987, 11114256, 14776713, 14801082, 24723456, 43122598, 46504845, 50065436, 50168465, 57315782, 85177295, 85753305, 96026020, 104046804, 104334847, 126650576, 126683279, 134338008, 135253190, 135785545, 137001349, 142214143, 160698609, 160963582, 163213628, 177749680, 178101510, 179338235, 198950509, 198973023, 223519262, 223686602, 226420981, 241124852, 241169861, 246640544
SuperDrug ATC ID
N06AX18
SuperDrug CAS ID
cas=098769814
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [535127]
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 468039(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4808).
Ref 536306Emerging treatments for depression. Expert Opin Pharmacother. 2006 Dec;7(17):2323-39.
Ref 535127Reboxetine: the first selective noradrenaline re-uptake inhibitor. Expert Opin Pharmacother. 2000 May;1(4):771-82.

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