Drug Information

Drug General Information
Drug ID
D0N8YG
Former ID
DNC006059
Drug Name
1-((S)-2-aminopropyl)-7-methyl-1H-indazol-6-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527952]
Structure
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2D MOL

3D MOL
Formula
C11H15N3O
Canonical SMILES
CC1=C2C(=CNN2CC(C)N)C=CC1=O
InChI
1S/C11H15N3O/c1-7(12)6-14-11-8(2)10(15)4-3-9(11)5-13-14/h3-5,7,13H,6,12H2,1-2H3
InChIKey
MIBVBASXMOZOBF-UHFFFAOYSA-N
PubChem Compound ID
11708276
Target and Pathway
Target(s) 5-hydroxytryptamine 2C receptor Target Info Inhibitor [527952]
5-hydroxytryptamine 2B receptor Target Info Inhibitor [527952]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [527952]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, Other
References
Ref 527952J Med Chem. 2006 Jan 12;49(1):318-28.1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.
Ref 527952J Med Chem. 2006 Jan 12;49(1):318-28.1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.

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