Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0NE3C
|
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| Former ID |
DCL000061
|
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| Drug Name |
AZD3409
|
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| Drug Type |
Small molecular drug
|
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| Therapeutic Class |
Anticancer Agents
|
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| Company |
AstraZeneca
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C29H39FN4O3S2
|
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| InChI |
InChI=1S/C29H39FN4O3S2/c1-19(2)37-28(35)26(12-15-38-4)33-20(3)25-16-23(8-7-21(25)11-13-30)32-18-24-9-10-27(34-24)39-29(36)22-6-5-14-31-17-22/h5-8,14,16-17,19,24,26-27,32-34H,3,9-13,15,18H2,1-2,4H3/t24-,26-,27-/m0/s1
|
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| InChIKey |
GIJNHMGFNKZBIR-URORMMCBSA-N
|
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| CAS Number |
CAS 345915-10-8
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Farnesyltransferase | Target Info | Inhibitor | [536218], [536277], [536283] | |
| WikiPathways | Visual phototransduction | ||||
| Apoptotic execution phase | |||||
| References | |||||
| Ref 542931 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8027). | ||||
| Ref 547315 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015097) | ||||
| Ref 536218 | Quantification of farnesylmethylcysteine in lysates of peripheral blood mononuclear cells using liquid chromatography coupled with electrospray tandem mass spectrometry: pharmacodynamic assay for farnesyl transferase inhibitors. Anal Chem. 2006 Apr 15;78(8):2617-22. | ||||
| Ref 536277 | Radiosensitizing effects of the prenyltransferase inhibitor AZD3409 against RAS mutated cell lines. Cancer Biol Ther. 2006 Sep;5(9):1206-10. Epub 2006 Sep 11. | ||||
| Ref 536283 | AZD3409 inhibits the growth of breast cancer cells with intrinsic resistance to the EGFR tyrosine kinase inhibitor gefitinib. Breast Cancer Res Treat. 2007 May;102(3):275-82. Epub 2006 Sep 27. | ||||
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