Drug Information

Drug General Information
Drug ID
D0NG7O
Former ID
DAP000077
Drug Name
Zolmitriptan
Synonyms
AscoTop; Flezol; Zolmitriptane; Zolmitriptanum; Zomig; Zomigon; Zolmitriptan RapidFilm; Zolmitriptan [USAN]; Zomig Nasal Spray; Zomig ZMT; AscoTop (TN); BW-311C90; KS-5072; Zomig (TN); Zomig-ZMT; Zomigon (TN); Zomigoro (TN); Zomig, Zomigon, AscoTopand, Zomigoro, Zolmitriptan; (4S)-4-({3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}methyl)-1,3-oxazolidin-2-one; (4S)-4-[[3-(2-dimethylaminoethyl)-1H-indol-5-yl]methyl]-1,3-oxazolidin-2-one; (S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)-2-oxazolidinone; (S)-4-((3-(2-(Dimethylamino)ethyl)indol-5-yl)methyl)-2-oxazolidinone; (S)-4-[3-(2-Dimethylamino-ethyl)-1H-indol-5-ylmethyl]-oxazolidin-2-one; (S)-4-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone; 4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)-2-oxazolidinone; 4-[[3-(2-dimethylaminoethyl)-1H-indol-5-yl]methyl]oxazolidin-2-one
Drug Type
Small molecular drug
Indication Migraine [ICD9: 346; ICD10:G43] Approved [538555], [541265]
Therapeutic Class
Antimigraine Agents
Company
AstraZeneca
Structure
Download
2D MOL

3D MOL
Formula
C16H21N3O2
InChI
InChI=1S/C16H21N3O2/c1-19(2)6-5-12-9-17-15-4-3-11(8-14(12)15)7-13-10-21-16(20)18-13/h3-4,8-9,13,17H,5-7,10H2,1-2H3,(H,18,20)/t13-/m0/s1
InChIKey
ULSDMUVEXKOYBU-ZDUSSCGKSA-N
CAS Number
CAS 139264-17-8
PubChem Compound ID
60857
PubChem Substance ID
9427, 7847481, 7980917, 8187100, 11484392, 11488544, 11528684, 12014671, 14897880, 14922369, 26612872, 26680025, 26719749, 43118195, 46386880, 46386934, 46506452, 46530532, 49681573, 50730852, 57314155, 91011737, 92124588, 92308124, 92308640, 93166198, 96099961, 103346351, 103941674, 104179250, 104253285, 104321827, 117664449, 118855343, 124636835, 124757406, 124801240, 125164210, 126656630, 126667001, 129386325, 135017989, 135651366, 135692210, 135693782, 136974858, 137171693, 142742126, 144076376, 144205008
ChEBI ID
ChEBI:10124
SuperDrug ATC ID
N02CC03
SuperDrug CAS ID
cas=139264178
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Modulator [556264]
5-hydroxytryptamine 1D receptor Target Info Modulator [556264]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
References
Ref 538555FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 020768.
Ref 541265(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 60).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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