TTD | Drug: D0NK8D

Drug General Information
Drug ID	D0NK8D
Former ID	DNC004456
Drug Name	SC-53228
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Terminated	[546132]
Structure		Download 2D MOL 3D MOL
Formula	C31H41NO7
Canonical SMILES	CCCC1=C(C=CC2=C1OC(CC2)CCC(=O)O)OCCCOC3=C(C(=C(C=C3)C(=<br />O)NC)OC)CC4CC4
InChI	1S/C31H41NO7/c1-4-6-23-26(14-10-21-9-11-22(39-29(21)23)12-16-28(33)34)37-17-5-18-38-27-15-13-24(31(35)32-2)30(36-3)25(27)19-20-7-8-20/h10,13-15,20,22H,4-9,11-12,16-19H2,1-3H3,(H,32,35)(H,33,34)/t22-/m0/s1
InChIKey	YWYUQSGYKDEAMJ-QFIPXVFZSA-N
PubChem Compound ID	204058
Target and Pathway
Target(s)	Leukotriene B4 receptor 1	Target Info	Inhibitor	[551272]
KEGG Pathway	Neuroactive ligand-receptor interaction
NetPath Pathway	IL4 Signaling Pathway
Reactome	Leukotriene receptors
Reactome	G alpha (q) signalling events
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546132	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006478)
Ref 551272	Synthesis and pharmacological activity of SC-53228, a leukotriene B4 receptor antagonist with high intrinsic potency and selectivity, Bioorg. Med. Chem. Lett. 4(6):811-816 (1994).

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Drug Information