Drug Information

Drug General Information
Drug ID
D0NM1F
Former ID
DNC010175
Drug Name
(R)-N-isopropyl-N-(pyrrolidin-3-yl)-2-naphthamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530367]
Structure
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2D MOL

3D MOL
Formula
C18H22N2O
Canonical SMILES
CC(C)N(C1CCNC1)C(=O)C2=CC3=CC=CC=C3C=C2
InChI
1S/C18H22N2O/c1-13(2)20(17-9-10-19-12-17)18(21)16-8-7-14-5-3-4-6-15(14)11-16/h3-8,11,13,17,19H,9-10,12H2,1-2H3/t17-/m1/s1
InChIKey
ZQHFQDYTXXQENI-QGZVFWFLSA-N
PubChem Compound ID
45487774
Target and Pathway
Target(s) Sodium-dependent serotonin transporter Target Info Inhibitor [530367]
Sodium-dependent noradrenaline transporter Target Info Inhibitor [530367]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter ActivityWP727:Monoamine Transport
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 530367Bioorg Med Chem Lett. 2009 Oct 15;19(20):5893-7. Epub 2009 Aug 21.Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2.
Ref 530367Bioorg Med Chem Lett. 2009 Oct 15;19(20):5893-7. Epub 2009 Aug 21.Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2.

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