Drug General Information
Drug ID	D0NV9C
Former ID	DNC010717
Drug Name	2-(4-bromophenylsulfonamido)-N-hydroxyacetamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530746]
Structure		Download 2D MOL 3D MOL
Formula	C8H9BrN2O4S
Canonical SMILES	C1=CC(=CC=C1S(=O)(=O)NCC(=O)NO)Br
InChI	1S/C8H9BrN2O4S/c9-6-1-3-7(4-2-6)16(14,15)10-5-8(12)11-13/h1-4,10,13H,5H2,(H,11,12)
InChIKey	AKOBMMAQXVKOJR-UHFFFAOYSA-N
PubChem Compound ID	22004198
Target and Pathway
Target(s)	ADAM 17	Target Info	Inhibitor	[530746]
	Matrix metalloproteinase-14	Target Info	Inhibitor	[530746]
KEGG Pathway	Notch signaling pathway
	Alzheimer's disease
	Epithelial cell signaling in Helicobacter pylori infectionhsa04668:TNF signaling pathway
	GnRH signaling pathway
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Alzheimer disease-presenilin pathway
	Notch signaling pathwayP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database	ErbB4 signaling events
	TNF receptor signaling pathway
	p75(NTR)-mediated signalinghif2pathway:HIF-2-alpha transcription factor network
	Signaling events mediated by focal adhesion kinase
Reactome	Nuclear signaling by ERBB4
	Collagen degradation
	Regulated proteolysis of p75NTR
	Activated NOTCH1 Transmits Signal to the Nucleus
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 t(7
	M1580_K2555) Translocation Mutant
	Constitutive Signaling by NOTCH1 HD Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	TNF signaling
	Growth hormone receptor signalingR-HSA-1442490:Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
WikiPathways	Notch Signaling Pathway
	Copper homeostasis
	Notch Signaling Pathway
	Growth hormone receptor signaling
	BDNF signaling pathway
	Alzheimers Disease
	Signalling by NGF
	Extrinsic Pathway for ApoptosisWP615:Senescence and Autophagy in Cancer
	Activation of Matrix Metalloproteinases
	Degradation of collagen
	AGE/RAGE pathway
	Matrix Metalloproteinases
References
Ref 530746	J Med Chem. 2010 Mar 25;53(6):2622-35.Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models.
Ref 530746	J Med Chem. 2010 Mar 25;53(6):2622-35.Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models.

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