Drug Information

Drug General Information
Drug ID
D0O0JB
Former ID
DIB007070
Drug Name
PSMA-targeted tubulysin B conjugates
Synonyms
DUPA-TubH III; DUPA-tubulysin III; EC-1069; PSMA-targeted tubulysin B conjugates (prostate cancer); PSMA-targeted tubulysin B conjugates (prostate cancer), Endocyte/Purdue University
Indication Prostate cancer [ICD9: 185; ICD10:C61] Phase 1 [549705]
Company
Endocyte
Structure
Download
2D MOL

3D MOL
Canonical SMILES
c1(nc(sc1)[C@@H](C[C@@H](N(C(=O)[C@@H](NC(=O)[C@@H]1N(C<br />)CCCC1)[C@H](CC)C)COC(=O)CC(C)C)C(C)C)OC(=O)C)C(=O)N[C@<br />H](C[C@@H](C(=O)NNC(=O)OCCSSC[C@H](NC(=O)[C@@H](NC(=O)[<br />C@@H](NC(=O)CC[C@H](NC(=O)CC[C@H](NC(=O)N[C@H](C(=O)O)C<br />CC(=O)O)C(=O)O)C(=O)O)CC(=O)O)Cc1ccccc1)C(=O)O)C)Cc1ccc<br />(cc1)O
Target and Pathway
Target(s) Glutamate carboxypeptidase II Target Info Modulator [530072]
KEGG Pathway Alanine, aspartate and glutamate metabolism
Metabolic pathways
Vitamin digestion and absorption
NetPath Pathway TCR Signaling Pathway
TNFalpha Signaling Pathway
Reactome Amino acid synthesis and interconversion (transamination)
WikiPathways One Carbon Metabolism
References
Ref 549705J Clin Oncol 33, 2015 (suppl; abstr e13527)
Ref 530072Prostate-specific membrane antigen targeted imaging and therapy of prostate cancer using a PSMA inhibitor as a homing ligand. Mol Pharm. 2009 May-Jun;6(3):780-9.

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