Drug Information

Drug General Information
Drug ID
D0O1MP
Former ID
DIB009915
Drug Name
CARZELESIN
Synonyms
Carzelesin < Rec INN; U-80244; (S)-N-[2-[1-(Chloromethyl)-8-methyl-5-(N-phenylcarbamoyloxy)-1,2,3,6-tetrahydrobenzo[1,2-b:4,3-b']dipyrrol-3-ylcarbonyl]-1H-indol-5-yl]-6-(diethylamino)benzofuran-2-carboxamide
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Discontinued in Phase 2 [544949]
Structure
Download
2D MOL

3D MOL
Formula
C41H37ClN6O5
Canonical SMILES
CCN(CC)c1ccc2cc(oc2c1)C(=O)Nc3ccc4[nH]c(cc4c3)C(=O)N5C[<br />C@@H](CCl)c6c5cc(OC(=O)Nc7ccccc7)c8[nH]cc(C)c68
InChI
1S/C41H37ClN6O5/c1-4-47(5-2)29-13-11-24-17-35(52-33(24)18-29)39(49)44-28-12-14-30-25(15-28)16-31(46-30)40(50)48-22-26(20-42)37-32(48)19-34(38-36(37)23(3)21-43-38)53-41(51)45-27-9-7-6-8-10-27/h6-19,21,26,43,46H,4-5,20,22H2,1-3H3,(H,44,49)(H,45,51)/t26-/m1/s1
InChIKey
BBZDXMBRAFTCAA-AREMUKBSSA-N
CAS Number
CAS 119813-10-4
PubChem Compound ID
3034013
Target and Pathway
Target(s) Human DNA Target Info Binder [534807]
References
Ref 544949Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001664)
Ref 534807Sequence selectivity of DNA alkylation by adozelesin and carzelesin. Arch Pharm Res. 1998 Aug;21(4):385-90.

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