Drug Information

Drug General Information
Drug ID
D0O2YE
Former ID
DNC000745
Drug Name
HTF 919
Drug Type
Small molecular drug
Indication Constipation [ICD9: 564; ICD10:K59.0] Approved [546112], [551871]
Structure
Download
2D MOL

3D MOL
Formula
C16H23N5O
Canonical SMILES
CCCCCN=C(N)NNC=C1C=NC2=C1C=C(C=C2)CO
InChI
1S/C16H23N5O/c1-2-3-4-7-18-16(17)21-20-10-13-9-19-15-6-5-12(11-22)8-14(13)15/h5-6,8-10,20,22H,2-4,7,11H2,1H3,(H3,17,18,21)/b13-10+
InChIKey
URPUECXJHQGUDU-JLHYYAGUSA-N
CAS Number
CAS 189188-57-6
PubChem Compound ID
5487301
PubChem Substance ID
29157335, 39473078, 46506519, 47434921, 48329128, 50064441, 50070902, 57364259, 79145050, 85209871, 113994948, 131285777, 134339464, 134340089, 137003313, 138069539, 138798190, 152104537, 160964413, 226406643, 229781970, 233757876, 237307805
ChEBI ID
ChEBI:51044
SuperDrug ATC ID
N06BA01
SuperDrug CAS ID
cas=000300629
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Agonist [535385]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 546112Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006410)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 5353855-Hydroxytryptamine mediated contractions in isolated preparations of equine ileum and pelvic flexure: pharmacological characterization of a new 5-HT(4) agonist. J Vet Pharmacol Ther. 2002 Feb;25(1):49-58.

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