Drug General Information
Drug ID	D0O4BC
Former ID	DNC003833
Drug Name	3-(2-Benzylamino-ethoxy)-phenol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534787]
Structure		Download 2D MOL 3D MOL
Formula	C15H17NO2
Canonical SMILES	C1=CC=C(C=C1)CNCCOC2=CC=CC(=C2)O
InChI	1S/C15H17NO2/c17-14-7-4-8-15(11-14)18-10-9-16-12-13-5-2-1-3-6-13/h1-8,11,16-17H,9-10,12H2
InChIKey	VBTFJGYCISLKEQ-UHFFFAOYSA-N
PubChem Compound ID	11776546
Target and Pathway
Target(s)	D(3) dopamine receptor	Target Info	Inhibitor	[525599]
	D(2) dopamine receptor	Target Info	Inhibitor	[525599]
	D(4) dopamine receptor	Target Info	Inhibitor	[525599]
	5-hydroxytryptamine 1A receptor	Target Info	Inhibitor	[534787]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Dopaminergic synapsehsa04015:Rap1 signaling pathway
	cAMP signaling pathway
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Alcoholismhsa04080:Neuroactive ligand-receptor interaction
	Dopaminergic synapsehsa04024:cAMP signaling pathway
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Dopamine receptors
	G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
	G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
	GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
	Genes and (Common) Pathways Underlying Drug Addiction
	Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
	GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
References
Ref 534787	Bioorg Med Chem Lett. 1998 Feb 3;8(3):295-300.New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates.
Ref 525599	Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8.New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template.
Ref 534787	Bioorg Med Chem Lett. 1998 Feb 3;8(3):295-300.New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates.

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