Drug Information

Drug General Information
Drug ID
D0O4CV
Former ID
DIB009258
Drug Name
Dihydroergotamine nasal
Synonyms
Dihydroergotamine; Levadex; Tempo Migraine; Inhaled DHE, Sheffield; MAP-0004; Tempo dyhydroergotamine, Sheffield; Nasal DHE (migraine), Britannia; Dihydroergotamine (inhaled, Tempo), MAP; Dihydroergotamine (nasal, migraine), Britannia; Dihydroergotamine (inhaled/oral, Tempo), Sheffield; Dihydroergotamine (migraine,Tempo-inhaled/oral), MAP
Indication Migraine [ICD9: 346; ICD10:G43] Approved [551730]
Therapeutic Class
Neurology Agents
Company
Britannia Pharmaceuticals Ltd; allergan; map pharmaceuticals
Structure
Download
2D MOL

3D MOL
Canonical SMILES
[C@@]12(N(C(=O)[C@@](O1)(NC(=O)[C@@H]1C[C@H]3[C@H](N(C1<br />)C)Cc1c4c3cccc4[nH]c1)C)[C@H](C(=O)N1[C@H]2CCC1)Cc1cccc<br />c1)O
CAS Number
CAS 511-12-6
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Modulator [534635]
5-hydroxytryptamine 1D receptor Target Info Modulator [534635]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
References
Ref 551730Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75.
Ref 534635Br J Pharmacol. 1998 Apr;123(8):1655-65.Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines.

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