Drug General Information
Drug ID	D0O6HP
Former ID	DCL000141
Drug Name	KAI-9803
Drug Type	Small molecular drug
Indication	Reperfusion injury and heart attacks; Acute myocardial infarction [ICD9: 410; ICD10:I21, I21-I22, I22]		Phase 1/2	[536497], [542782]
Company	KAI Pharma.
Structure		Download 2D MOL 3D MOL
Formula	C120H199N45O34S2
CAS Number	CAS 1818-68-4
PubChem Compound ID	56843747
PubChem Substance ID	135268321
Target and Pathway
Target(s)	Protein kinase C, delta type	Target Info	Inhibitor	[536615], [536788], [537459]
KEGG Pathway	Chemokine signaling pathway
	Vascular smooth muscle contraction
	Tight junction
	Fc epsilon RI signaling pathway
	Fc gamma R-mediated phagocytosis
	Neurotrophin signaling pathway
	Inflammatory mediator regulation of TRP channels
	GnRH signaling pathway
	Estrogen signaling pathway
	Type II diabetes mellitus
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Alzheimer disease-amyloid secretase pathway
	Angiogenesis
	Apoptosis signaling pathway
	B cell activation
	EGF receptor signaling pathway
	Endothelin signaling pathway
	FGF signaling pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
	VEGF signaling pathway
	Wnt signaling pathway
	5HT2 type receptor mediated signaling pathway
	Histamine H1 receptor mediated signaling pathway
	Oxytocin receptor mediated signaling pathway
	Thyrotropin-releasing hormone receptor signaling pathway
	CCKR signaling map ST
Pathway Interaction Database	Endothelins
	LPA receptor mediated events
	Thromboxane A2 receptor signaling
	Role of Calcineurin-dependent NFAT signaling in lymphocytes
	IGF1 pathway
	Ceramide signaling pathway
	IFN-gamma pathway
	ErbB1 downstream signaling
	Syndecan-4-mediated signaling events
	IL6-mediated signaling events
	PDGFR-beta signaling pathway
	Hedgehog signaling events mediated by Gli proteins
	Signaling events mediated by VEGFR1 and VEGFR2
	PAR1-mediated thrombin signaling events
	Syndecan-2-mediated signaling events
	Validated transcriptional targets of TAp63 isoforms
	p53 pathway
	Trk receptor signaling mediated by the MAPK pathway
	Trk receptor signaling mediated by PI3K and PLC-gamma
	Alpha-synuclein signaling
Reactome	Apoptotic cleavage of cellular proteins
	Calmodulin induced events
	Effects of PIP2 hydrolysis
	DAG and IP3 signaling
	Role of phospholipids in phagocytosis
	G alpha (z) signalling events
	HuR (ELAVL1) binds and stabilizes mRNA
	VEGFR2 mediated cell proliferation
	CLEC7A (Dectin-1) signaling
	Interferon gamma signaling
WikiPathways	TCR Signaling Pathway
	Type II interferon signaling (IFNG)
	Calcium Regulation in the Cardiac Cell
	Insulin Signaling
	EGF/EGFR Signaling Pathway
	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	MAPK Signaling Pathway
	IL-6 signaling pathway
	G Protein Signaling Pathways
	Myometrial Relaxation and Contraction Pathways
	Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
	DAG and IP3 signaling
	Alpha 6 Beta 4 signaling pathway
	BDNF signaling pathway
	Oncostatin M Signaling Pathway
	Corticotropin-releasing hormone
	AGE/RAGE pathway
	B Cell Receptor Signaling Pathway
	Signaling Pathways in Glioblastoma
	miRs in Muscle Cell Differentiation
	Opioid Signalling
	GPCR downstream signaling
	Effects of PIP2 hydrolysis
	Apoptotic execution phase
	Type II diabetes mellitus
References
Ref 536497	Pharmacologic therapeutics for cardiac reperfusion injury. Expert Opin Emerg Drugs. 2007 Sep;12(3):367-88.
Ref 542782	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7840).
Ref 536615	Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. Circulation. 2008 Feb 19;117(7):886-96. Epub 2008 Feb 4.
Ref 536788	Letter by Metzler et al regarding article, "Intracoronary KAI-9803 as an adjunct to primary coronary intervention for acute ST-segment elevation myocardial infarction". Circulation. 2008 Jul 22;118(4):e80.
Ref 537459	PKC delta and epsilon in drug targeting and therapeutics. Recent Pat DNA Gene Seq. 2009;3(2):96-101.

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