Drug Information

Drug General Information
Drug ID
D0O7DN
Former ID
DIB002216
Drug Name
CEP-427
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Terminated [546139]
Company
Cephalon Inc
Target and Pathway
Target(s) Tumor necrosis factor receptor superfamily member 16 Target Info Modulator [543520]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Neurotrophin signaling pathway
Transcriptional misregulation in cancer
Pathway Interaction Database p75(NTR)-mediated signaling
Neurotrophic factor-mediated Trk receptor signaling
Reactome Axonal growth inhibition (RHOA activation)
NRAGE signals death through JNK
p75NTR negatively regulates cell cycle via SC1
Regulated proteolysis of p75NTR
NADE modulates death signalling
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Axonal growth stimulation
WikiPathways Spinal Cord Injury
BDNF signaling pathway
Signalling by NGF
References
Ref 546139Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006555)
Ref 543520(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1888).

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