Drug General Information
Drug ID	D0O8JW
Former ID	DIB001268
Drug Name	Ronomilast
Synonyms	ELB-353; PDE4 inhibitor, BioTie; PDE4 inhibitor, elbion; AWD-12-353
Drug Type	Small molecular drug
Indication	Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47]		Phase 1	[547206]
Company	Elbion AG
Structure		Download 2D MOL 3D MOL
Formula	C21H13Cl2FN4O2
Canonical SMILES	c1(cn(c2c1cccn2)Cc1ccc(F)cc1)C(=O)C(=O)Nc1c(Cl)cncc1Cl
CAS Number	CAS 418794-42-0
PubChem Compound ID	9803446
Target and Pathway
Target(s)	CAMP-specific 3',5'-cyclic phosphodiesterase 4B	Target Info	Inhibitor	[550312]
	Type IV phosphodiesterase	Target Info	Inhibitor	[550312]
	CAMP-specific 3',5'-cyclic phosphodiesterase 4A	Target Info	Inhibitor	[550312]
KEGG Pathway	Purine metabolism
	cAMP signaling pathway
	Morphine addictionhsa00230:Purine metabolism
	Morphine addiction
NetPath Pathway	IL5 Signaling Pathway
	IL2 Signaling Pathway
PathWhiz Pathway	Purine Metabolism
Reactome	DARPP-32 events
	G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
	G alpha (s) signalling events
WikiPathways	G Protein Signaling Pathways
	Myometrial Relaxation and Contraction Pathways
	Nuclear Receptors Meta-Pathway
	Opioid SignallingWP35:G Protein Signaling Pathways
	TSH signaling pathwayWP35:G Protein Signaling Pathways
References
Ref 547206	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013990)
Ref 550312	Clinical pipeline report, company report or official report of Avarx.

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