Drug Information

Drug General Information
Drug ID
D0OB7B
Former ID
DNC009954
Drug Name
2-(1,4'-bipiperidin-1'-yl)thiazolo[4,5-b]pyridine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530397]
Structure
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2D MOL

3D MOL
Formula
C16H22N4S
Canonical SMILES
C1CCN(CC1)C2CCN(CC2)C3=NC4=C(S3)C=CC=N4
InChI
1S/C16H22N4S/c1-2-9-19(10-3-1)13-6-11-20(12-7-13)16-18-15-14(21-16)5-4-8-17-15/h4-5,8,13H,1-3,6-7,9-12H2
InChIKey
LHPSMXXBNXLHOD-UHFFFAOYSA-N
PubChem Compound ID
45482707
Target and Pathway
Target(s) Histamine H3 receptor Target Info Inhibitor [530397]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 530397Bioorg Med Chem Lett. 2009 Nov 1;19(21):6176-80. Epub 2009 Sep 6.Synthesis and structure-activity relationships of 2-(1,4'-bipiperidin-1'-yl)thiazolopyridine as H3 receptor antagonists.
Ref 530397Bioorg Med Chem Lett. 2009 Nov 1;19(21):6176-80. Epub 2009 Sep 6.Synthesis and structure-activity relationships of 2-(1,4'-bipiperidin-1'-yl)thiazolopyridine as H3 receptor antagonists.

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