Drug Information

Drug General Information
Drug ID
D0OQ5H
Former ID
DNC010922
Drug Name
6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-N-(HYDROXYMETHYL)-1,2,2-TRIMETHYL-1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE-4-CARBOXAMIDE (ENANTIOMERIC MIX)
Drug Type
Small molecular drug
Indication Ovarian cancer [ICD9: 183; ICD10:C56] Investigative [530929]
Structure
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2D MOL

3D MOL
Formula
C25H24Cl3N3O2
PubChem Compound ID
46891330
Target and Pathway
Target(s) Cannabinoid receptor 2 Target Info Inhibitor [530929]
Potassium voltage-gated channel subfamily H member 2 Target Info Inhibitor [530929]
Cannabinoid receptor 1 Target Info Inhibitor [530929]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04015:Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
PathWhiz Pathway Muscle/Heart Contraction
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-1296072:Voltage gated Potassium channelsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Potassium ChannelsWP455:GPCRs, Class A Rhodopsin-like
BDNF signaling pathway
GPCR downstream signaling
GPCRs, Other
References
Ref 530929Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. Epub 2010 Apr 21.Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation.
Ref 530929Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. Epub 2010 Apr 21.Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation.

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