Drug General Information
Drug ID
D0OR8W
Former ID
DIB012163
Drug Name
ETIPREDNOL DICLOACETATE
Synonyms
BNP-166; Cronaze (Ivax); Ethinase (Ivax); Etiprednol dicloacetate < USAN; Prop INN >; Respicort (Ivax); (11beta,17alpha)-17-(2,2-Dichloroacetoxy)-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylic acid ethyl ester
Drug Type
Small molecular drug
Indication Rhinitis [ICD9: 472.0, 477; ICD10:J00, J30, J31.0] Phase 2 [521510]
Company
Teva Pharmaceutical USA
Structure
Download
2D MOL

3D MOL

Formula
C24H30Cl2O6
Canonical SMILES
CCOC(=O)[C@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H<br />]3[C@@H](O)C[C@]12C)OC(=O)C(Cl)Cl
InChI
1S/C24H30Cl2O6/c1-4-31-21(30)24(32-20(29)19(25)26)10-8-16-15-6-5-13-11-14(27)7-9-22(13,2)18(15)17(28)12-23(16,24)3/h7,9,11,15-19,28H,4-6,8,10,12H2,1-3H3/t15-,16-,17-,18+,22-,23-,24-/m0/s1
InChIKey
QAIOVDNCIZSSSF-RFAJLIJZSA-N
CAS Number
CAS 199331-40-3
PubChem Compound ID
Target and Pathway
Target(s) Glucocorticoid receptor Target Info Modulator
KEGG Pathway Neuroactive ligand-receptor interaction
NetPath Pathway IL2 Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
FOXA2 and FOXA3 transcription factor networks
Glucocorticoid receptor regulatory network
Regulation of Androgen receptor activity
AP-1 transcription factor network
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expression
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
SIDS Susceptibility Pathways
Nuclear Receptors Meta-Pathway
Endoderm Differentiation
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Adipogenesis
Circadian Clock
Nuclear Receptors
References
Ref 521510ClinicalTrials.gov (NCT00035503) Multicenter Trial For Patients With Acute Crohn's Disease. U.S. National Institutes of Health.

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