Drug Information

Drug General Information
Drug ID
D0OS8C
Former ID
DIB009617
Drug Name
NCX-1015
Synonyms
Nitroprednisolone; NCX-1004; NCX-1016; NO-prednisolone
Indication Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Phase 1 [526716]
Company
NicOx SA
Structure
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2D MOL

3D MOL
Canonical SMILES
[C@]12([C@@](C(=O)COC(=O)c3ccc(CO[N+](=O)[O-])cc3)(CC[C<br />@H]1[C@H]1[C@@H]([C@@]3(C(=CC(=O)C=C3)CC1)C)[C@H](C2)O)<br />O)C
CAS Number
CAS 327610-87-7
Target and Pathway
Target(s) Glucocorticoid receptor Target Info Modulator [526716]
KEGG Pathway Neuroactive ligand-receptor interaction
NetPath Pathway IL2 Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
FOXA2 and FOXA3 transcription factor networks
Glucocorticoid receptor regulatory network
Regulation of Androgen receptor activity
AP-1 transcription factor network
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expression
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
SIDS Susceptibility Pathways
Nuclear Receptors Meta-Pathway
Endoderm Differentiation
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Adipogenesis
Circadian Clock
Nuclear Receptors
References
Ref 526716Glucocorticoid receptor nitration leads to enhanced anti-inflammatory effects of novel steroid ligands. J Immunol. 2003 Sep 15;171(6):3245-52.
Ref 526716Glucocorticoid receptor nitration leads to enhanced anti-inflammatory effects of novel steroid ligands. J Immunol. 2003 Sep 15;171(6):3245-52.

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