Drug General Information
Drug ID	D0OZ2F
Former ID	DNC011808
Drug Name	AP-7
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[526787]
Structure		Download 2D MOL 3D MOL
Formula	C7H16NO5P
Canonical SMILES	C(CCC(C(=O)O)N)CCP(=O)(O)O
InChI	1S/C7H16NO5P/c8-6(7(9)10)4-2-1-3-5-14(11,12)13/h6H,1-5,8H2,(H,9,10)(H2,11,12,13)
InChIKey	MYDMWESTDPJANS-UHFFFAOYSA-N
PubChem Compound ID	3122
Target and Pathway
Target(s)	NMDA receptor subunit NR1	Target Info	Inhibitor	[526787]
	Glutamate [NMDA] receptor subunit epsilon 2	Target Info	Inhibitor	[526787]
	Glutamate [NMDA] receptor subunit epsilon 1	Target Info	Inhibitor	[526787]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Circadian entrainment
	Long-term potentiation
	Glutamatergic synapse
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)
	Huntington's disease
	Cocaine addiction
	Amphetamine addiction
	Nicotine addiction
	Alcoholismhsa04014:Ras signaling pathway
	Dopaminergic synapse
	Alcoholism
	Systemic lupus erythematosushsa04014:Ras signaling pathway
	Systemic lupus erythematosus
PANTHER Pathway	Huntington disease
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database	ErbB4 signaling events
	Reelin signaling pathwayreelinpathway:Reelin signaling pathway
Reactome	EPHB-mediated forward signaling
	Unblocking of NMDA receptor, glutamate binding and activation
	CREB phosphorylation through the activation of CaMKII
	Ras activation uopn Ca2+ infux through NMDA receptor
	RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
	RAF/MAP kinase cascadeR-HSA-438066:Unblocking of NMDA receptor, glutamate binding and activation
	RAF/MAP kinase cascade
WikiPathways	SIDS Susceptibility Pathways
	Hypothetical Network for Drug Addiction
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Spinal Cord Injury
	BDNF signaling pathway
	Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
	BDNF signaling pathwayWP666:Hypothetical Network for Drug Addiction
	Alzheimers Disease
References
Ref 526787	J Med Chem. 1992 Dec 11;35(25):4720-6.Bioisosteric replacement of the alpha-amino carboxylic acid functionality in 2-amino-5-phosphonopentanoic acid yields unique 3,4-diamino-3-cyclobutene-1,2-dione containing NMDA antagonists.
Ref 526787	J Med Chem. 1992 Dec 11;35(25):4720-6.Bioisosteric replacement of the alpha-amino carboxylic acid functionality in 2-amino-5-phosphonopentanoic acid yields unique 3,4-diamino-3-cyclobutene-1,2-dione containing NMDA antagonists.

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