Drug Information

Drug General Information
Drug ID
D0P0HB
Former ID
DAP001141
Drug Name
Ethionamide
Synonyms
Aethionamidum; Aetina; Aetiva; Amidazin; Amidazine; Atina; Ethatyl; Ethimide; Ethina; Ethinamide; Ethionamidum; Ethioniamide; Ethylisothiamide; Ethyonomide; Etimid; Etiocidan; Etionamid; Etionamida; Etionamide; Etioniamid; Etionid; Etionizin; Etionizina; Etionizine; Fatoliamid; Iridocin; Iridozin; Isothin; Isotiamida; Itiocide; Nicotion; Nisotin; Nizotin; Rigenicid; Sertinon; Teberus; Thianid; Thianide; Thioamide; Thiomid; Thioniden; Tianid; Tiomid; Trecator; Trekator; Trescatyl; Trescazide; Tubenamide; Tubermin; Tuberoid; Tuberoson; Ethionamid prothionamid; Etionamide [DCIT]; Iridocin Bayer; Trecator SC; Wyeth Brand of Ethionamide; Bayer 5312; Bayer5312; E0695; TH 1314; Alpha-Ethylisonicotinic acid thioamide; Alpha-Ethylisonicotinoylthioamide; Alpha-Ethylisothionicotinamide; Alpha-Ethylthioisonicotinamide; Alpha-ethylt hioisonicotinamide; Ethina (VAN); Ethionamidum [INN-Latin]; Etionamida [INN-Spanish]; Tio-Mid; Trecator-SC; Alpha-Ethyl-thioisonicotinamide; Trecator-SC (TN); Ethionamide (JP15/USP/INN); Ethionamide [USAN:INN:BAN:JAN]; 2-ETHYL-4-PYRIDINECARBOTHIOAMIDE; 2-Ethyl-4-thioamidylpyridine; 2-Ethyl-4-thiocarbamoylpyridine; 2-Ethyl-thioisonicotinamide; 2-Ethylisonicotinic acid thioamide; 2-Ethylisonicotinic thioamide; 2-Ethylisonicotinothioamide; 2-Ethylisonicotinoylthioamide; 2-Ethylisothionicotinamide; 2-Ethylthioisonicotinamide; 2-e thylisothionicotinamide; 2-ethyl-4-aminothiocarbonylpyridine; 2-ethylisonicotinic acid thiomide; 2-ethylpyridine-4-carbothioamide; 2-ethylthioisonicotinamide, Trecator SC, Amidazine, Ethionamide; 3-Ethylisothionicotinamide
Drug Type
Small molecular drug
Indication Tuberculosis [ICD9: 010-018; ICD10:A15-A19] Approved [536472], [551871]
Therapeutic Class
Antituberculosis Agents
Structure
Download
2D MOL

3D MOL
Formula
C8H10N2S
Canonical SMILES
CCC1=NC=CC(=C1)C(=S)N
InChI
1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11)
InChIKey
AEOCXXJPGCBFJA-UHFFFAOYSA-N
CAS Number
CAS 536-33-4
PubChem Compound ID
2761171
PubChem Substance ID
9867, 138261, 602897, 3189207, 5235093, 7847657, 7979199, 8149340, 8815239, 10321785, 10525861, 11112402, 11335320, 11360559, 11363976, 11366538, 11369100, 11371336, 11374352, 11377262, 11461531, 11466554, 11467674, 11484823, 11486168, 11488810, 11490244, 11492362, 11494896, 11532957, 15413224, 17389895, 24894350, 26611740, 26679347, 26747295, 26747296, 26752898, 39176212, 46506077, 47365040, 47515175, 47515176, 47588853, 47959584, 48184860, 48334345, 48413732, 48415974, 48423391
ChEBI ID
ChEBI:4885
SuperDrug ATC ID
J04AD03
SuperDrug CAS ID
cas=000536334
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Enoyl-[acyl-carrier-protein] reductase [NADH] Target Info Inhibitor [536338], [536947]
References
Ref 536472Novel agents in the management of Mycobacterium tuberculosis disease. Curr Med Chem. 2007;14(18):2000-8.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536338Mechanism of thioamide drug action against tuberculosis and leprosy. J Exp Med. 2007 Jan 22;204(1):73-8. Epub 2007 Jan 16.
Ref 536947Calcium-activated conductance in skate electroreceptors: current clamp experiments. J Gen Physiol. 1977 Feb;69(2):121-43.

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