TTD | Drug: D0P2BY

Drug General Information
Drug ID	D0P2BY
Former ID	DNC009296
Drug Name	[2-(Benzoimidazol-1-yl)ethyl]-bisphosphonic acid
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529758]
Structure		Download 2D MOL 3D MOL
Formula	C9H12N2O6P2
Canonical SMILES	C1=CC=C2C(=C1)N=CN2CC(P(=O)(O)O)P(=O)(O)O
InChI	1S/C9H12N2O6P2/c12-18(13,14)9(19(15,16)17)5-11-6-10-7-3-1-2-4-8(7)11/h1-4,6,9H,5H2,(H2,12,13,14)(H2,15,16,17)
InChIKey	ISSICOMKRRPVPD-UHFFFAOYSA-N
PubChem Compound ID	5277505
Target and Pathway
Target(s)	Farnesyl pyrophosphatesynthetase	Target Info	Inhibitor	[529758]
KEGG Pathway	Terpenoid backbone biosynthesis
	Metabolic pathways
	Biosynthesis of antibiotics
	Influenza A
	HTLV-I infection
PathWhiz Pathway	Steroid Biosynthesis
Reactome	Cholesterol biosynthesis
Reactome	Activation of gene expression by SREBF (SREBP)
WikiPathways	Activation of Gene Expression by SREBP (SREBF)
	SREBP signalling
	Cholesterol Biosynthesis
References
Ref 529758	J Med Chem. 2008 Nov 13;51(21):6800-7. Epub 2008 Oct 21.Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism.
Ref 529758	J Med Chem. 2008 Nov 13;51(21):6800-7. Epub 2008 Oct 21.Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism.

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Drug Information