Drug Information

Drug General Information
Drug ID
D0P2HR
Former ID
DIB018301
Drug Name
[3H]granisetron
Synonyms
[3H]-granisetron; [3H]-BRL-43694
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539443]
Structure
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2D MOL

3D MOL
Formula
C18H24N4O
InChI
InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)
InChIKey
MFWNKCLOYSRHCJ-UHFFFAOYSA-N
PubChem Compound ID
3510
Target and Pathway
Target(s) 5-hydroxytryptamine receptor 3A Target Info Antagonist [534215]
5-HT3AB Target Info Antagonist [526116]
KEGG Pathway Serotonergic synapse
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway 5HT3 type receptor mediated signaling pathway
Reactome Ligand-gated ion channel transport
WikiPathways SIDS Susceptibility Pathways
Iron uptake and transport
References
Ref 539443(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2292).
Ref 526116Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors. Neuropharmacology. 2001 Aug;41(2):282-4.
Ref 534215Characterization of a human 5-hydroxytryptamine3 receptor type A (h5-HT3R-AS) subunit stably expressed in HEK 293 cells. Br J Pharmacol. 1996 Jul;118(5):1237-45.

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