Drug General Information
Drug ID	D0P3HP
Former ID	DNC012674
Drug Name	1,2,3,4,4a,5,10,10a-Octahydro-benzo[g]quinoline
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534719]
Structure		Download 2D MOL 3D MOL
Formula	C13H17N
Canonical SMILES	C1CC2CC3=CC=CC=C3CC2NC1
InChI	1S/C13H17N/c1-2-5-11-9-13-12(6-3-7-14-13)8-10(11)4-1/h1-2,4-5,12-14H,3,6-9H2
InChIKey	PXDWMPVOPNRION-UHFFFAOYSA-N
PubChem Compound ID	20186598
Target and Pathway
Target(s)	Alpha-2B adrenergic receptor	Target Info	Inhibitor	[534719]
	Alpha-2A adrenergic receptor	Target Info	Inhibitor	[534719]
	Alpha-2C adrenergic receptor	Target Info	Inhibitor	[534719]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	G alpha (i) signalling events
	G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (z) signalling events
	Surfactant metabolismR-HSA-390696:Adrenoceptors
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	GPCR ligand binding
	GPCR downstream signalingWP58:Monoamine GPCRs
	Integration of energy metabolism
	GPCR downstream signaling
References
Ref 534719	J Med Chem. 1998 Oct 8;41(21):4165-70.N-(Iodopropenyl)-octahydrobenzo[f]- and -[g]quinolines: synthesis and adrenergic and dopaminergic activity studies.
Ref 534719	J Med Chem. 1998 Oct 8;41(21):4165-70.N-(Iodopropenyl)-octahydrobenzo[f]- and -[g]quinolines: synthesis and adrenergic and dopaminergic activity studies.

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