Drug General Information
Drug ID
D0P4KF
Former ID
DNC005068
Drug Name
2-(4-tert-Butyl-phenyl)-4,5-dihydro-1H-imidazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527180]
Structure
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2D MOL

3D MOL

Formula
C13H18N2
Canonical SMILES
CC(C)(C)C1=CC=C(C=C1)C2=NCCN2
InChI
1S/C13H18N2/c1-13(2,3)11-6-4-10(5-7-11)12-14-8-9-15-12/h4-7H,8-9H2,1-3H3,(H,14,15)
InChIKey
JRUYKUSXUFPDNO-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Alpha-1A adrenergic receptor Target Info Inhibitor [527180]
5-hydroxytryptamine 1D receptor Target Info Inhibitor [527180]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
AMPK SignalingWP722:Serotonin HTR1 Group and FOS Pathway
References
Ref 527180Bioorg Med Chem Lett. 2004 Sep 20;14(18):4697-9.2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands.
Ref 527180Bioorg Med Chem Lett. 2004 Sep 20;14(18):4697-9.2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands.

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