Drug Information

Drug General Information
Drug ID
D0P4MU
Former ID
DNC005968
Drug Name
7-ethyloxyethoxy-2-morpholin-4-yl-chromen-4-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527888]
Structure
Download
2D MOL

3D MOL
Formula
C17H21NO5
Canonical SMILES
CCOCCOC1=CC2=C(C=C1)C(=O)C=C(O2)N3CCOCC3
InChI
1S/C17H21NO5/c1-2-20-9-10-22-13-3-4-14-15(19)12-17(23-16(14)11-13)18-5-7-21-8-6-18/h3-4,11-12H,2,5-10H2,1H3
InChIKey
ICGVDPFEKFHPNV-UHFFFAOYSA-N
PubChem Compound ID
11529823
Target and Pathway
Target(s) DNA-dependent protein kinase catalytic subunit Target Info Inhibitor [527888]
KEGG Pathway Non-homologous end-joining
Cell cycle
NetPath Pathway IL1 Signaling Pathway
Pathway Interaction Database DNA-PK pathway in nonhomologous end joining
Coregulation of Androgen receptor activity
Class I PI3K signaling events mediated by Akt
BARD1 signaling events
Reactome Nonhomologous End-Joining (NHEJ)
WikiPathways DNA Damage Response
Non-homologous end joining
FAS pathway and Stress induction of HSP regulation
Cytosolic sensors of pathogen-associated DNA
Retinoblastoma (RB) in Cancer
Prostate Cancer
Double-Strand Break Repair
Cell Cycle
miRNA Regulation of DNA Damage Response
References
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.

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