Drug Information

Drug General Information
Drug ID
D0P6UB
Former ID
DAP000573
Drug Name
Methamphetamine
Synonyms
Crank; Desohyephedrine; Desyphed; Metamfetamina; Metamfetamine; Metamfetaminum; Metamphetamine; Meth; Methamphetaminum; Methylamphetamine; Norodin; Speed; Stimulex; Crank [Street Name]; Crystal Meth; Crystal Meth [Street Name]; Desyphed hydrochloride; ICE [Street Name]; Metamfetamine [INN];Metamfetaminum [Latin]; Metanfetamina [Spanish]; Methamphetaminum [JP]; Speed [Street Name]; D-Deoxyephedrine; D-Desoxyephedrine; D-Methamphetamine; D-Methylamphetamine; D-Phenylisopropylmethylamine;Desoxyn (TN); L-Methamphetamine; Metamfetamina [INN-Spanish]; Metamfetamine (INN); Metamfetamine-m; Metamfetaminum [INN-Latin]; Metanfetamina [INN-Spanish]; Meth (Street Name); Methamphetaminum [INN-Latin]; N-Methylamphetamine; D-N-Methylamphetamine; Methyl-beta-phenylisopropylamine; D-(S)-Methamphetamine; D-N,alpha-dimethylphenethylamine; Methamphetamine, its salts, isomers, and salts of its isomers; N-Methyl-beta-phenylisopropylamin; N-Methyl-beta-phenylisopropylamin [German]; N-Methyl-beta-phenylisopropylamine; D-1-Phenyl-2-methylaminopropan; D-1-Phenyl-2-methylaminopropan [German]; D-1-Phenyl-2-methylaminopropane; Methyl-.beta.-phenylisopropylamine; S-(+)-Methamphetamine; D-N,.alpha.-Dimethylphenethylamine; N-Methyl-1-phenyl-2-propanamine; Benzeneethanamine, N,alpha-dimethyl-, (S)-(9CI); Benzeneethanamine, N,alpha-dimethyl-, (alphaS)-(9CI); Phenethylamine, N,alpha-dimethyl-, (S)-(+)-(8CI); (+)-(S)-Deoxyephedrine; (+)-(S)-N-alpha-Dimethylphenethylamine; (+)-2-(N-Methylamino)-1-phenylpropane; (+)-Methylamphetamine; (+)-N,alpha-Dimethyl-beta-phenylethylamine; (+)-N,alpha-Dimethylphenethylamine; (+)-N-Methylamphetamine; (+)-methamphetamine; (2S)-N-methyl-1-phenylpropan-2-amine; (S)-(+)-Deoxyephedrine; (S)-(+)-Methamphetamine; (S)-(+)-N,alpha,dimethylphenethylamine; (S)-Methamphetamine; (S)-Methylamphetamine; (S)-N,alpha-Dimethylbenzeneethanamine; (S)-N,alpha-Dimethylbenzeneethanoamine; (alphaS)-N,alpha-dimethylbenzeneethanamine; 1-Phenyl-2-methylamino-propan; 1-Phenyl-2-methylamino-propan [German]; 1-Phenyl-2-methylaminopropane; 2S-(+)-Methamphetamine
Drug Type
Small molecular drug
Indication Attention deficit hyperactivity disorder [ICD9: 314; ICD10:F90] Approved [468034], [538186]
Therapeutic Class
Central Nervous System Stimulants
Company
Ovation Pharma
Structure
Download
2D MOL

3D MOL
Formula
C10H15N
InChI
InChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3/t9-/m0/s1
InChIKey
MYWUZJCMWCOHBA-VIFPVBQESA-N
CAS Number
CAS 537-46-2
PubChem Compound ID
10836
PubChem Substance ID
9373, 86393, 841176, 7979916, 8157860, 10318874, 15194699, 29229287, 46508541, 47217054, 47365454, 47515585, 47960002, 50004327, 53789276, 56311093, 56312330, 56313865, 56314133, 56314533, 57288565, 57326508, 76939162, 85239987, 96024877, 104234344, 104324404, 117516537, 128667762, 134337864, 134338686, 134977993, 136963523, 137001219, 142148255, 160964817, 164187274, 175268005, 175269473, 175443906, 178101505, 179252637, 184547219, 223856686, 226427302, 241092821, 250138934, 250231443
ChEBI ID
ChEBI:6809
SuperDrug ATC ID
N06BA03
SuperDrug CAS ID
cas=000537462
Target and Pathway
Target(s) Alpha-1B adrenergic receptor Target Info Antagonist [536897]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
AMPK Signaling
References
Ref 468034(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4803).
Ref 538186FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040529.
Ref 536897Mirtazapine treatment after conditioning with methamphetamine alters subsequent expression of place preference. Drug Alcohol Depend. 2009 Jan 1;99(1-3):231-9. Epub 2008 Oct 21.

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