Drug Information

Drug General Information
Drug ID
D0P8AW
Former ID
DNC012276
Drug Name
Ro-21-7767
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533759]
Structure
Download
2D MOL

3D MOL
Formula
C18H19NO2
Canonical SMILES
CN1CC2=CC=CC=C2C3C1CCC4=C3C=CC(=C4O)O
InChI
1S/C18H19NO2/c1-19-10-11-4-2-3-5-12(11)17-13-7-9-16(20)18(21)14(13)6-8-15(17)19/h2-5,7,9,15,17,20-21H,6,8,10H2,1H3/t15-,17-/m1/s1
InChIKey
GFOJCADGVHYVJC-NVXWUHKLSA-N
PubChem Compound ID
11778475
Target and Pathway
Target(s) Dopamine D1 receptor Target Info Inhibitor [533759]
D(2) dopamine receptor Target Info Inhibitor [533759]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholismhsa04015:Rap1 signaling pathway
Alcoholism
PANTHER Pathway Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 533759J Med Chem. 1995 Jan 20;38(2):318-27.Evaluation of cis- and trans-9- and 11-hydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as structurally rigid, selective D1 dopamine receptor ligands.
Ref 533759J Med Chem. 1995 Jan 20;38(2):318-27.Evaluation of cis- and trans-9- and 11-hydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as structurally rigid, selective D1 dopamine receptor ligands.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.