Drug Information

Drug General Information
Drug ID
D0P8JA
Former ID
DNC003597
Drug Name
Ro-04-6790
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539784]
Structure
Download
2D MOL

3D MOL
Formula
C12H16N6O2S
InChI
InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18)
InChIKey
JELFWSXQTXRMAJ-UHFFFAOYSA-N
PubChem Compound ID
5312145
PubChem Substance ID
7980531, 11056903, 11111728, 12015219, 14752063, 26755720, 39341763, 47721695, 47870812, 48095630, 48244483, 48244484, 50111226, 53092140, 57359528, 85209259, 85787460, 90340990, 99381440, 103230014, 103989000, 114157993, 124750194, 124881320, 124881321, 128263141, 134340802, 135650909, 135698492, 140775890, 141679203, 163123420, 179235839, 204360712, 225053443, 226973665, 241376163, 242242309, 249617709, 251963225, 252156869
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [529929]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 539784(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 274).
Ref 529929J Med Chem. 2009 Feb 12;52(3):675-87.Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists.

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