Drug General Information
Drug ID	D0P8PK
Former ID	DNC005586
Drug Name	6-(3-Hydroxy-phenyl)-naphthalen-2-ol
Synonyms	6-(3-hydroxyphenyl)-2-naphthol; 6-(3-hydroxyphenyl)naphthalen-2-ol
Indication	Discovery agent		Investigative	[528496]
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C1=CC(=CC(=C1)O)C2=CC3=C(C=C2)C=C(C=C3)O
InChI	1S/C16H12O2/c17-15-3-1-2-11(9-15)12-4-5-14-10-16(18)7-6-13(14)8-12/h1-10,17-18H
InChIKey	VHWBXEUHUQDHDH-UHFFFAOYSA-N
Target and Pathway
Target(s)	Estrogen receptor	Target Info	Inhibitor	[527584]
	Cytochrome P450 3A4	Target Info	Inhibitor	[529359]
	Estradiol 17 beta-dehydrogenase 1	Target Info	Inhibitor	[529595]
	Tyrosine oxidase	Target Info	Inhibitor	[528496]
	Estrogen receptor beta	Target Info	Inhibitor	[527584]
BioCyc Pathway	Superpathway of steroid hormone biosynthesis
	Estradiol biosynthesis IPWY-6133:(S)-reticuline biosynthesis
	Eumelanin biosynthesis
	L-dopachrome biosynthesis
KEGG Pathway	Estrogen signaling pathway
	Prolactin signaling pathway
	Thyroid hormone signaling pathway
	Endocrine and other factor-regulated calcium reabsorption
	Proteoglycans in cancerhsa00140:Steroid hormone biosynthesis
	Linoleic acid metabolism
	Retinol metabolism
	Metabolism of xenobiotics by cytochrome P450
	Drug metabolism - cytochrome P450
	Drug metabolism - other enzymes
	Metabolic pathways
	Bile secretion
	Chemical carcinogenesishsa00140:Steroid hormone biosynthesis
	Ovarian steroidogenesishsa00350:Tyrosine metabolism
	Riboflavin metabolism
	Melanogenesishsa04915:Estrogen signaling pathway
NetPath Pathway	FSH Signaling Pathway
	EGFR1 Signaling Pathway
	RANKL Signaling PathwayNetPath_25:FSH Signaling Pathway
PANTHER Pathway	Androgen/estrogene/progesterone biosynthesis
Pathway Interaction Database	Regulation of nuclear SMAD2/3 signaling
	Signaling events mediated by HDAC Class II
	Plasma membrane estrogen receptor signaling
	LKB1 signaling events
	Regulation of Telomerase
	ATF-2 transcription factor network
	AP-1 transcription factor network
	FOXM1 transcription factor network
	Validated nuclear estrogen receptor alpha network
	Signaling mediated by p38-alpha and p38-beta
	FOXA1 transcription factor networker_nongenomic_pathway:Plasma membrane estrogen receptor signaling
	Validated nuclear estrogen receptor beta network
PathWhiz Pathway	Caffeine Metabolism
	Retinol MetabolismPW000045:Androgen and Estrogen MetabolismPW000035:Riboflavin Metabolism
	Tyrosine Metabolism
Reactome	Nuclear signaling by ERBB4
	Nuclear Receptor transcription pathwayR-HSA-211981:Xenobiotics
	Aflatoxin activation and detoxificationR-HSA-2453902:The canonical retinoid cycle in rods (twilight vision)R-HSA-383280:Nuclear Receptor transcription pathway
WikiPathways	Estrogen signaling pathway
	Nuclear Receptors Meta-Pathway
	Estrogen Receptor Pathway
	Signaling by ERBB4
	JAK/STAT
	Integrated Pancreatic Cancer Pathway
	Leptin signaling pathway
	miR-targeted genes in muscle cell - TarBase
	Integrated Breast Cancer Pathway
	Nuclear ReceptorsWP702:Metapathway biotransformation
	Aflatoxin B1 metabolism
	Estrogen metabolism
	Benzo(a)pyrene metabolism
	Tamoxifen metabolism
	Tryptophan metabolism
	Oxidation by Cytochrome P450
	Nuclear Receptors in Lipid Metabolism and Toxicity
	Farnesoid X Receptor Pathway
	Vitamin D Receptor Pathway
	Felbamate Metabolism
	Lidocaine metabolism
	Nifedipine Activity
	Colchicine Metabolic Pathway
	Irinotecan Pathway
	Drug Induction of Bile Acid Pathway
	Fatty Acid Omega Oxidation
	Codeine and Morphine MetabolismWP496:Steroid Biosynthesis
	Metabolism of steroid hormones and vitamin D
	Prostate CancerWP2436:Dopamine metabolismWP706:SIDS Susceptibility Pathways
	Ovarian Infertility Genes
	Nuclear Receptors
References
Ref 528496	Bioorg Med Chem Lett. 2007 Jan 15;17(2):461-4. Epub 2006 Oct 12.Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase.
Ref 527584	J Med Chem. 2005 Jun 16;48(12):3953-79.ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity.
Ref 528496	Bioorg Med Chem Lett. 2007 Jan 15;17(2):461-4. Epub 2006 Oct 12.Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase.
Ref 529359	J Med Chem. 2008 Apr 10;51(7):2158-69. Epub 2008 Mar 7.Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases.
Ref 529595	J Med Chem. 2008 Aug 14;51(15):4685-98. Epub 2008 Jul 17.Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design, synthesis, biological evaluation, and pharmacokinetics.

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