Drug Information

Drug General Information
Drug ID
D0P9EL
Former ID
DIB002161
Drug Name
AS-601811
Synonyms
4,8-Dimethyl-2,3,5,6-tetrahydro-1H-benzo[c]quinolizin-3-one
Drug Type
Small molecular drug
Indication Acne vulgaris [ICD9: 706.1; ICD10:L70.0] Discontinued in Phase 1 [547124]
Structure
Download
2D MOL

3D MOL
Formula
C15H17NO
Canonical SMILES
CC1=CC2=C(C=C1)N3CCC(=O)C(=C3CC2)C
InChI
1S/C15H17NO/c1-10-3-5-14-12(9-10)4-6-13-11(2)15(17)7-8-16(13)14/h3,5,9H,4,6-8H2,1-2H3
InChIKey
SNEPAAKJPPNOQM-UHFFFAOYSA-N
PubChem Compound ID
10220187
PubChem Substance ID
15220594, 22609088, 40334680, 79944162, 103345449, 103990611, 129260660, 172649634, 198991045, 223745952, 232504722
Target and Pathway
Target(s) 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Target Info Inhibitor [526428], [547125]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Allopregnanolone biosynthesis
Androgen biosynthesis
KEGG Pathway Steroid hormone biosynthesis
NetPath Pathway IL2 Signaling Pathway
PathWhiz Pathway Androgen and Estrogen Metabolism
Reactome Androgen biosynthesis
References
Ref 547124Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013228)
Ref 526428Pharmacokinetics and pharmacodynamics of TF-505, a novel nonsteroidal 5alpha-reductase inhibitor, in normal subjects treated with single or multiple doses. Br J Clin Pharmacol. 2002 Sep;54(3):283-94.
Ref 547125Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013228)

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