Drug General Information
Drug ID	D0P9KA
Former ID	DIB016578
Drug Name	YM-16151-4
Synonyms	YM-151; YM-16151-1; (-)-YM-16151-1
Drug Type	Small molecular drug
Indication	Hypertension [ICD9: 401; ICD10:I10-I16]		Phase 1	[533693]
Company	Yamanouchi Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C30H37N3O9
Canonical SMILES	C1(=C(NC(=C(C1c1cc([N+](=O)[O-])ccc1OCCCCNCC(COc1ccccc1<br />)O)C(=O)OC)C)C)C(=O)OC.Cl
PubChem Compound ID	128387
Target and Pathway
Target(s)	Beta-1 adrenergic receptor	Target Info	Modulator	[533693]
	Calcium channel	Target Info	Modulator	[533693]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Adrenergic signaling in cardiomyocytes
	Gap junction
	Salivary secretion
	Dilated cardiomyopathy
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Beta1 adrenergic receptor signaling pathway
PathWhiz Pathway	Muscle/Heart Contraction
Reactome	Adrenoceptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Endothelin Pathways
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 533693	Antianginal effects of YM-16151-4 in various experimental angina models. J Cardiovasc Pharmacol. 1993 May;21(5):701-8.
Ref 533693	Antianginal effects of YM-16151-4 in various experimental angina models. J Cardiovasc Pharmacol. 1993 May;21(5):701-8.

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