Drug Information

Drug General Information
Drug ID
D0PA5S
Former ID
DAP000658
Drug Name
Risedronate
Synonyms
Benet; RIS; Ridron; Acide risedronique; Acido risedronico; Acidum risedronicum; Risedronic acid; Bisphosphonate 1; NE 58019; Acide risedronique [INN-French]; Acido risedronico [INN-Spanish]; Acidum risedronicum [INN-Latin]; Actonel (TN); Ridron (TN); Risedronic acid (INN); Risedronic acid [INN:BAN]; (1-Hydroxy-2-(3-pyridyl)ethylidene)diphosphonic acid; (1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphonic acid; (1-hydroxy-2-pyridin-3-ylethane-1,1-diyl)bis(phosphonic acid); 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID
Drug Type
Small molecular drug
Indication Paget's disease [ICD9: 731; ICD10:M88] Approved [537304], [540158]
Therapeutic Class
Bone Density Conservation Agents
Company
Procter & Gamble; Sanofi-Aventis
Structure
Download
2D MOL

3D MOL
Formula
C7H11NO7P2
InChI
InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
InChIKey
IIDJRNMFWXDHID-UHFFFAOYSA-N
CAS Number
CAS 105462-24-6
PubChem Compound ID
5245
PubChem Substance ID
10432, 634947, 854702, 854710, 5611888, 7890278, 7980522, 8024683, 8153227, 14799749, 26717653, 29224300, 46506784, 46507526, 46513033, 48416522, 50064108, 50489232, 53790968, 56479319, 57322678, 81040440, 81063165, 92309057, 92712985, 93166168, 96025170, 103240839, 104308679, 125337191, 126625112, 126656394, 126670227, 128171553, 131293655, 134337947, 134340432, 135018951, 135650902, 135692314, 136990826, 137003756, 142093192, 143493311, 144080110, 152031983, 152242566, 160964225, 162178465, 164205287
SuperDrug ATC ID
M05BA07
SuperDrug CAS ID
cas=105462246
Target and Pathway
Target(s) Farnesyl pyrophosphatesynthetase Target Info Inhibitor [535496]
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Influenza A
HTLV-I infection
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF)
SREBP signalling
Cholesterol Biosynthesis
References
Ref 537304Risedronate for treatment of osteoporosis. Nippon Rinsho. 2009 May;67(5):948-53.
Ref 540158(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3176).
Ref 535496Activity of bisphosphonates against Trypanosoma brucei rhodesiense. J Med Chem. 2002 Jul 4;45(14):2904-14.

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