Drug Information

Drug General Information
Drug ID
D0PB0D
Former ID
DIB000585
Drug Name
SRX-251
Synonyms
AVN-246; SRX-108; SRX-31; SRX-74; Vasopressin V1a antagonist (Raynauds disease/dysmenorrhea), Azevan Pharmaceuticals; Vasopressin V1a antagonist (psychiatric disorders/dysmenorrhea), Azevan
Indication Dysmenorrhea [ICD9: 625.3; ICD10:N94.4-N94.6] Phase 1 [548381]
Company
Azevan Pharmaceuticals Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
[C@@H]1(COC(=O)N1[C@@H]1C(=O)N([C@@H](C(=O)N(C)Cc2cc(C(<br />F)(F)F)ccc2)CC(=O)N2CCC(CC2)N2CCCCC2)[C@@H]1/C=C/c1cccc<br />c1)c1ccccc1
Target and Pathway
Target(s) Vasopressin V1a receptor Target Info Antagonist [528051]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Reactome Vasopressin-like receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 548381Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025117)
Ref 528051Orally active vasopressin V1a receptor antagonist, SRX251, selectively blocks aggressive behavior. Pharmacol Biochem Behav. 2006 Feb;83(2):169-74. Epub 2006 Feb 28.

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