Drug General Information
Drug ID	D0PC2C
Former ID	DNC011820
Drug Name	3-Ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[526822]
Structure		Download 2D MOL 3D MOL
Formula	C12H17NO
Canonical SMILES	CCN1CCC2=C(CC1)C(=CC=C2)O
InChI	1S/C12H17NO/c1-2-13-8-6-10-4-3-5-12(14)11(10)7-9-13/h3-5,14H,2,6-9H2,1H3
InChIKey	HTCXSPINZBVTNI-UHFFFAOYSA-N
PubChem Compound ID	10261961
Target and Pathway
Target(s)	5-hydroxytryptamine 1A receptor	Target Info	Inhibitor	[526822]
	D(2) dopamine receptor	Target Info	Inhibitor	[526822]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapsehsa04015:Rap1 signaling pathway
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Alcoholism
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Serotonin receptors
	G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
References
Ref 526822	J Med Chem. 1992 Oct 30;35(22):3984-90.6-Hydroxy-3-n-propyl-2,3,4,5-tetrahydro-1H-3-benzazepine and analogs: new centrally acting 5-HT1A receptor agonists.
Ref 526822	J Med Chem. 1992 Oct 30;35(22):3984-90.6-Hydroxy-3-n-propyl-2,3,4,5-tetrahydro-1H-3-benzazepine and analogs: new centrally acting 5-HT1A receptor agonists.

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