Drug Information

Drug General Information
Drug ID
D0PI1C
Former ID
DIB020014
Drug Name
HQL-79
Synonyms
HQL79; HQL 79
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541768]
Structure
Download
2D MOL
Formula
C22H27N5O
InChI
InChI=1S/C22H27N5O/c1-3-8-18(9-4-1)22(19-10-5-2-6-11-19)28-20-13-16-27(17-14-20)15-7-12-21-23-25-26-24-21/h1-6,8-11,20,22H,7,12-17H2,(H,23,24,25,26)
InChIKey
TZQGXAHOROZEKN-UHFFFAOYSA-N
PubChem Compound ID
6540277
PubChem Substance ID
11110093, 14779957, 17137156, 43185427, 46394035, 78840335, 99444388, 103698647, 104154489, 114617208, 123220338, 125317241, 125334115, 129336962, 137184564, 137615999, 160968975, 162012042, 164759453, 172840953, 175437918, 178103274, 184538738, 184816006, 202558391, 226681828, 241376499, 242060247, 250136882, 252157330, 252367711, 252450260, 252457239, 252543562
Target and Pathway
Target(s) Glutathione S-transferase Target Info Inhibitor [528089]
BioCyc Pathway C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
WikiPathways Arachidonic acid metabolism
Aryl Hydrocarbon Receptor
Integrated Pancreatic Cancer Pathway
References
Ref 541768(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6662).
Ref 528089Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J Biol Chem. 2006 Jun 2;281(22):15277-86. Epub 2006 Mar 17.

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