Drug General Information
Drug ID	D0PN6C
Former ID	DIB013161
Drug Name	5-HT 6 receptor antagonists
Synonyms	IDDBCP247735
Indication	Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3]		Investigative	[552069]
Company	Schering-Plough Research Institute
Structure		Download 2D MOL 3D MOL
Canonical SMILES	O=S(=O)(c1ccc(c2c1cccc2)OC)N1C[C@H](C(=O)N2CCCNCC2)c2c1<br />cccc2
Target and Pathway
Target(s)	5-hydroxytryptamine 6 receptor	Target Info	Antagonist	[543365]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway	Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome	Serotonin receptors
	G alpha (s) signalling events
WikiPathways	Serotonin Receptor 4/6/7 and NR3C Signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 552069	The discovery and SAR of indoline-3-carboxamides--a new series of 5-HT6 antagonists. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3713-6
Ref 543365	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 11).

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