Drug General Information
Drug ID	D0PN9E
Former ID	DIB016057
Drug Name	SK-951
Indication	Gastrointestinal disease [ICD10:K00-K93]		Terminated	[546979]
Company	Sanwa Kagaku Kenkyusho Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c12c(cc(c(c1C[C@@H](O2)C)N)Cl)C(=O)NCCC12N(CCC1)CCC2.C(<br />=O)(/C=C/C(=O)O)O
CAS Number	CAS 166743-12-0
Target and Pathway
Target(s)	5-hydroxytryptamine 4 receptor	Target Info	Agonist	[525467]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT4 type receptor mediated signaling pathway
PathWhiz Pathway	Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome	Serotonin receptors
	G alpha (s) signalling events
WikiPathways	Serotonin Receptor 4/6/7 and NR3C Signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546979	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011740)
Ref 525467	Identification of SK-951, a novel benzofuran derivative, as an agonist to 5-HT4 receptors. Jpn J Pharmacol. 1999 Feb;79(2):203-12.

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