Drug Information

Drug General Information
Drug ID
D0Q1UR
Former ID
DIB013738
Drug Name
TIAPAFANT
Synonyms
PCA-4248; 2,4,6-Trimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-(2-phenylthio)ethyl diester
Drug Type
Small molecular drug
Indication Septic shock [ICD9: 785.52; ICD10:A41.9] Terminated [541326], [545057]
Structure
Download
2D MOL

3D MOL
Formula
C19H23NO4S
InChI
InChI=1S/C19H23NO4S/c1-12-16(18(21)23-4)13(2)20-14(3)17(12)19(22)24-10-11-25-15-8-6-5-7-9-15/h5-9,12,20H,10-11H2,1-4H3
InChIKey
DHCNAWNKZMNTIS-UHFFFAOYSA-N
CAS Number
CAS 123875-01-4
PubChem Compound ID
4698
PubChem Substance ID
5601115, 8152884, 11120345, 11120833, 11121321, 11121682, 11122162, 11362748, 11365310, 11367872, 11370767, 11370768, 11373473, 11376034, 14779097, 26751776, 26751777, 29223784, 47290935, 47959527, 50104463, 51958183, 57322404, 58005752, 81093348, 85087783, 85788284, 89364513, 92310033, 99300945, 99302465, 103330468, 103828650, 104307165, 106157682, 117583461, 126407971, 135084228, 135515809, 135698036, 143556218, 144087360, 162022682, 162105869, 162273725, 162781980, 169957901, 178102701, 204362274, 215667297
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Antagonist [531635], [533646]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 541326(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6080).
Ref 545057Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001989)
Ref 531635Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.
Ref 533646PCA-4248, a PAF receptor antagonist, inhibits PAF-induced phosphoinositide turnover. Eur J Pharmacol. 1995 Aug 15;290(3):183-8.

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