Drug Information

Drug General Information
Drug ID
D0Q5PC
Former ID
DNC011875
Drug Name
PHENCYCLIDINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467620]
Structure
Download
2D MOL

3D MOL
Formula
C17H25N
InChI
InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
InChIKey
JTJMJGYZQZDUJJ-UHFFFAOYSA-N
CAS Number
CAS 77-10-1
PubChem Compound ID
6468
PubChem Substance ID
9778, 834903, 841141, 5501449, 7885098, 7980287, 8154127, 10535449, 14749651, 29225444, 46394322, 46508889, 47217202, 47589403, 47960162, 48416405, 50016869, 53787096, 53787541, 57323466, 75325665, 103168867, 103915210, 104312147, 117358123, 124953686, 125332495, 128324845, 134349080, 134972150, 135331394, 137001267, 139012441, 152042164, 160644701, 160966681, 163229342, 164764207, 172656498, 175443921, 178101099, 179226011, 198957747, 223533765, 226426904, 241142333, 250075876, 252658643
Target and Pathway
Target(s) NMDA receptor subunit NR1 Target Info Inhibitor [534286]
Glutamate [NMDA] receptor subunit epsilon 2 Target Info Inhibitor [534286]
Glutamate [NMDA] receptor subunit epsilon 1 Target Info Inhibitor [534286]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Cocaine addiction
Amphetamine addiction
Nicotine addiction
Alcoholismhsa04014:Ras signaling pathway
Dopaminergic synapse
Alcoholism
Systemic lupus erythematosushsa04014:Ras signaling pathway
Systemic lupus erythematosus
PANTHER Pathway Huntington disease
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database ErbB4 signaling events
Reelin signaling pathwayreelinpathway:Reelin signaling pathway
Reactome EPHB-mediated forward signaling
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
RAF/MAP kinase cascadeR-HSA-438066:Unblocking of NMDA receptor, glutamate binding and activation
RAF/MAP kinase cascade
WikiPathways SIDS Susceptibility Pathways
Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Spinal Cord Injury
BDNF signaling pathway
Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
BDNF signaling pathwayWP666:Hypothetical Network for Drug Addiction
Alzheimers Disease
References
Ref 467620(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4282).
Ref 534286J Med Chem. 1996 Nov 22;39(24):4844-52.Synthesis and biological activity of conformationally restricted analogs of milnacipran: (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide, an efficient noncompetitive N-methyl-D-aspartic acid receptor antagonist.

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