Drug Information

Drug General Information
Drug ID
D0Q5SL
Former ID
DNC001654
Drug Name
BRL54443
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540549]
Structure
Download
2D MOL

3D MOL
Formula
C14H18N2O
InChI
InChI=1S/C14H18N2O/c1-16-6-4-10(5-7-16)13-9-15-14-3-2-11(17)8-12(13)14/h2-3,8-10,15,17H,4-7H2,1H3
InChIKey
WKNFADCGOAHBPG-UHFFFAOYSA-N
PubChem Compound ID
2438
PubChem Substance ID
5580999, 8151627, 11110825, 11113936, 15220671, 26752089, 29221602, 47365411, 47440474, 48185186, 50104743, 77824568, 85208985, 90341506, 104300587, 124749544, 124879371, 124879372, 124879373, 125093101, 125568956, 129594833, 135698379, 136368024, 137005651, 144115754, 152344534, 162009742, 162023008, 162220574, 162957191, 164045135, 172648765, 178100756, 198966450, 210274835, 210280467, 216088069, 223380665, 223674589, 223702804, 223872422, 225362715, 229554251, 241182155, 242060374, 242181581, 249768037, 249860760, 250225738
Target and Pathway
Target(s) 5-hydroxytryptamine 1E receptor Target Info Agonist [535132]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540549(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3927).
Ref 535132Characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathway coupling. J Pharmacol Exp Ther. 2001 Apr;297(1):88-95.

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