Drug General Information
Drug ID
D0Q6IW
Former ID
DCL000632
Drug Name
Rosiglitazone + simvastatin
Drug Type
Small molecular drug
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Phase 3 [550971]
Company
GSK
Structure
Download
2D MOL

3D MOL

Formula
C13H11N3O2
Canonical SMILES
COC1=CC2=C(C=C1)NC(=O)C2=CC3C=NC=N3
InChI
1S/C13H11N3O2/c1-18-9-2-3-12-10(5-9)11(13(17)16-12)4-8-6-14-7-15-8/h2-8H,1H3,(H,16,17)/b11-4-
InChIKey
KKGJVFQBVRACGR-WCIBSUBMSA-N
CAS Number
CAS 122320-73-4
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Peroxisome proliferator activated receptor gamma Target Info Agonist [550963]
KEGG Pathway PPAR signaling pathway
AMPK signaling pathway
Osteoclast differentiation
Huntington's disease
Pathways in cancer
Transcriptional misregulation in cancer
Thyroid cancer
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway CCKR signaling map ST
Pathway Interaction Database Noncanonical Wnt signaling pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by HDAC Class I
RXR and RAR heterodimerization with other nuclear receptor
Regulation of retinoblastoma protein
Reactome PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
WikiPathways Wnt Signaling Pathway Netpath
Nuclear Receptors in Lipid Metabolism and Toxicity
Differentiation of white and brown adipocyte
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional Regulation of White Adipocyte Differentiation
Adipogenesis
SREBP signalling
Nuclear Receptors
References
Ref 550971Clinical pipeline report, company report or official report of GlaxoSmithKline.
Ref 550963Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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