Drug Information

Drug General Information
Drug ID
D0Q6VK
Former ID
DNC001293
Drug Name
SB 272844
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535497]
Structure
Download
2D MOL

3D MOL
Formula
C32H39Cl3N10O4
Canonical SMILES
CN1C=C(C=C1C(=O)NC2=CN(C(=C2)C(=O)NC3=CN(C(=C3)C(=O)NCC<br />C(=N)N)C)C)NC(=O)C4=CC=C(C=C4)N(CCCl)CCCl.Cl
InChI
1S/C32H38Cl2N10O4.ClH/c1-41-18-22(14-25(41)30(46)37-11-8-28(35)36)39-32(48)27-16-23(19-43(27)3)40-31(47)26-15-21(17-42(26)2)38-29(45)20-4-6-24(7-5-20)44(12-9-33)13-10-34;/h4-7,14-19H,8-13H2,1-3H3,(H3,35,36)(H,37,46)(H,38,45)(H,39,48)(H,40,47);1H
InChIKey
BLSOATWWAGIRGE-UHFFFAOYSA-N
CAS Number
CAS 115308-98-0
PubChem Compound ID
6918104
PubChem Substance ID
12014352, 17194679, 43529499, 50620930, 57371799, 103669817, 114787443, 134340499, 227460899
Target and Pathway
Target(s) High affinity interleukin-8 receptor B Target Info Antagonist [535497]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Epithelial cell signaling in Helicobacter pylori infection
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Interleukin signaling pathway
Pathway Interaction Database IL8- and CXCR2-mediated signaling events
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 535497The selective CXCR2 antagonist SB272844 blocks interleukin-8 and growth-related oncogene-alpha-mediated inhibition of spontaneous neutrophil apoptosis. Pulm Pharmacol Ther. 2002;15(2):103-10.
Ref 535497The selective CXCR2 antagonist SB272844 blocks interleukin-8 and growth-related oncogene-alpha-mediated inhibition of spontaneous neutrophil apoptosis. Pulm Pharmacol Ther. 2002;15(2):103-10.

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