Drug Information

Drug General Information
Drug ID
D0Q7JC
Former ID
DIB011227
Drug Name
P-552-02
Synonyms
CF-552; KM-003; P-552; Sodium channel blocker (oral, dry mouth/ Sjogren's syndrome), Parion Sciences
Drug Type
Small molecular drug
Indication Cystic fibrosis [ICD9: 277; ICD10:E84] Phase 1/2 [467618], [523506]
Company
Parion Sciences Inc
Structure
Download
2D MOL

3D MOL
Formula
C19H26ClN7O4
InChI
InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-8-2-1-3-11-4-6-13(7-5-11)31-10-12(29)9-28/h4-7,12,28-29H,1-3,8-10H2,(H4,21,22,26)(H3,23,24,27,30)
InChIKey
NTRKMGDUWYBLMS-UHFFFAOYSA-N
PubChem Compound ID
10310524
PubChem Substance ID
15318258, 41376361, 78895969, 103492762, 104073765, 142599063, 175427611, 178101097, 224730846, 228170827, 239860094, 247327034
Target and Pathway
Target(s) Sodium channel Target Info Blocker [551923]
KEGG Pathway Dopaminergic synapse
Reactome Interaction between L1 and Ankyrins
References
Ref 467618(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4280).
Ref 523506ClinicalTrials.gov (NCT01369589) An Evaluation of the Impact of a Single Dose of P-552 on Oral Mucosal Wetness. U.S. National Institutes of Health.
Ref 551923US patent application no. 2014,0221,286, Sodium channel blockers reduce glucagon secretion.

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