Drug Information

Drug General Information
Drug ID
D0Q8CV
Former ID
DNCL002289
Drug Name
CDX-301
Indication Cancer; Hematopoietic stem cell transplantation [ICD9: 140-229; ICD10:C00-C96, Z00-Z99] Phase 2 [524740]
Target and Pathway
Target(s) FL cytokine receptor Target Info Inhibitor [533222]
KEGG Pathway Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Central carbon metabolism in cancer
References
Ref 524740ClinicalTrials.gov (NCT02129075) CDX-1401 and Poly-ICLC Vaccine Therapy With or Without CDX-301in Treating Patients With Stage IIB-IV Melanoma. U.S. National Institutes of Health.
Ref 533222Efficacy and safety of CDX-301, recombinant human Flt3L, at expanding dendritic cells and hematopoietic stem cells in healthy human volunteers. Bone Marrow Transplant. 2015 Jul;50(7):924-30.

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