Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0Q8ZP
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| Former ID |
DIB011985
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| Drug Name |
TDI-0033
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| Synonyms |
Gene therapy program (NGF receptor agonist); TDI-0033; TDI-0034; TDI-0035; TDI-0036; TDI-0038; TDI-0041; Gene therapy program (NGF receptor agonist), ALS Therapy Development Foundation
|
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| Indication | Motor neurone disease [ICD9: 335.2; ICD10:G12.2] | Investigative | [543520] | ||
| Company |
ALS Therapy Development Foundation Inc
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| Target and Pathway | |||||
| Target(s) | Tumor necrosis factor receptor superfamily member 16 | Target Info | Agonist | [543520] | |
| Pathway Interaction Database | p75(NTR)-mediated signaling | ||||
| Neurotrophic factor-mediated Trk receptor signaling | |||||
| Reactome | Axonal growth inhibition (RHOA activation) | ||||
| NRAGE signals death through JNK | |||||
| p75NTR negatively regulates cell cycle via SC1 | |||||
| Regulated proteolysis of p75NTR | |||||
| NADE modulates death signalling | |||||
| NRIF signals cell death from the nucleus | |||||
| p75NTR recruits signalling complexes | |||||
| NF-kB is activated and signals survival | |||||
| Axonal growth stimulation | |||||
| References | |||||
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