Drug Information

Drug General Information
Drug ID
D0Q9DK
Former ID
DAP000339
Drug Name
Nizatidine
Synonyms
Acinon; Antizid; Axid; Calmaxid; Cronizat; Distaxid; Galitidin; Gastrax; Naxidine; Niatidine; Nizatidina; Nizatidinum; Nizax; Nizaxid; Panaxid; Tazac; Ulcosol; Ulxid; Zanizal; Zinga; Axid Ar; Nizatidina [Spanish]; Nizatidinum [Latin]; Splendil ER; LY 139037; Acinon (TN); Axid (TN); LY-139037; Tazac (TN); ZE-101; ZL-101; Nizatidine (JAN/USP/INN); Nizatidine [USAN:BAN:INN:JAN]; N-(2-(((2-((Dimethylamino)methyl)-4-thiazolyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine; N-(4-(6-Methylamino-7-nitro-2-thia-5-aza-6-hepten-1-yl)-2-thiazolylmethyl)-N,N-dimethylamin; (E)-1-N'-[2-[[2-(dimethylaminomethyl)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine; (E)-N-[2-[[2-(dimethylaminomethyl)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-N'-methyl-2-nitroethene-1,1-diamine; (E)-N-{2-[({2-[(dimethylamino)methyl]-1,3-thiazol-4-yl}methyl)thio]ethyl}-N'-methyl-2-nitroethene-1,1-diamine
Drug Type
Small molecular drug
Indication Acid-reflux disorders [ICD9: 530.81; ICD10:K21] Approved [538300], [542265]
Therapeutic Class
Antiulcer Agents
Company
Eli Lilly
Structure
Download
2D MOL

3D MOL
Formula
C12H21N5O2S2
InChI
InChI=1S/C12H21N5O2S2/c1-13-11(6-17(18)19)14-4-5-20-8-10-9-21-12(15-10)7-16(2)3/h6,9,13-14H,4-5,7-8H2,1-3H3/b11-6+
InChIKey
SGXXNSQHWDMGGP-IZZDOVSWSA-N
CAS Number
CAS 76963-41-2
PubChem Compound ID
3033637
PubChem Substance ID
9479, 7847506, 7980136, 10047729, 11112849, 12012865, 14801956, 26719892, 36077514, 46386765, 46507554, 48395159, 48416335, 49648463, 49968698, 57352747, 80039644, 85175204, 85209480, 92308159, 92308434, 92711372, 93166919, 103091650, 103157346, 103189241, 111634652, 117377111, 117480196, 119526527, 124658842, 124801333, 124882685, 126630925, 131269073, 131326051, 134337651, 135011516, 135692320, 137005454, 142971063, 144075999, 144089140, 152040062, 160963930, 172080209, 177748315, 178103822, 179116550, 179148990
SuperDrug ATC ID
A02BA04
SuperDrug CAS ID
cas=076963412
Target and Pathway
Target(s) Histamine H2 receptor Target Info Antagonist [536916]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 538300FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 075616.
Ref 542265(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7248).
Ref 536916Does the use of nizatidine, as a pro-kinetic agent, improve gastric emptying in patients post-oesophagectomy? J Gastrointest Surg. 2009 Mar;13(3):432-7. Epub 2008 Nov 1.

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