Drug Information

Drug General Information
Drug ID
D0QC0W
Former ID
DNC006943
Drug Name
ZM-447439
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543081]
Structure
Download
2D MOL

3D MOL
Formula
C29H31N5O4
InChI
InChI=1S/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37-17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/h2-4,6-11,18-20H,5,12-17H2,1H3,(H,33,35)(H,30,31,32)
InChIKey
OGNYUTNQZVRGMN-UHFFFAOYSA-N
PubChem Compound ID
9914412
PubChem Substance ID
14884865, 24194000, 29215551, 45986066, 46514557, 49853967, 57373778, 62690437, 80087595, 85860329, 99008595, 99436911, 103482586, 103905341, 123055327, 124757001, 124892237, 125163806, 125333858, 126617500, 126661172, 126664675, 126730511, 131480757, 134344148, 134964439, 135698591, 136367301, 136367716, 136378426, 140726703, 143496932, 152058909, 152212817, 152233314, 152258094, 152344038, 160646933, 160815791, 162011439, 162023442, 162037436, 162193005, 162838419, 164193989, 164834284, 170474579, 172649973, 174474521, 174528805
Target and Pathway
Target(s) Aurora kinase A Target Info Inhibitor [528348]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M Transition
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteins
References
Ref 543081(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8353).
Ref 528348J Med Chem. 2006 Aug 10;49(16):4805-8.Accurate prediction of the relative potencies of members of a series of kinase inhibitors using molecular docking and MM-GBSA scoring.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.